The quick reply is that it actually should not matter, use no matter you discover most handy.
The longer reply is that changing between the 2 is pretty easy trigonometry, so choose a coordinate system and orientation that make the sport code cleanest.
Personally, I might hold the world axis-aligned and have a “focus level” or “have a look at level” additionally in axis-aligned area.
Then simply place your digicam at focus + (+x, +y, +z) and level the digicam at focus.
[Obviously you can use ± x and z to control which corner you’re looking from]
However even for those who selected to have the world rotated 45 levels, the world could have it is personal remodel (matrix) and you possibly can a number of any axis-aligned place by that matrix to rework it from “axis area” to “skewed world area”, so once more… Not onerous.
